What is knee osteoarthritis (OA)?
OA is a common condition that causes joints—such as the knee—to become stiff and painful. If you have been diagnosed with knee OA, you are among the 14 million Americans living with this condition.3
OA is a common condition that causes joints—such as the knee—to become stiff and painful. If you have been diagnosed with knee OA, you are among the 14 million Americans living with this condition.3
In a healthy knee, smooth cartilage covers and protects the ends of bones in the joint, allowing them to glide smoothly as you move.4
In a knee with OA, cartilage that acts as a cushion between bones breaks down [ ]5
The joint space narrows, which may cause bones to rub together [ ]5
The thick, slippery fluid (synovial fluid) that lubricates and reduces friction in the knee becomes thin and less effective6
If you have knee osteoarthritis, your doctor may recommend exercise and weight loss to help reduce knee pain and stiffness.8 Exercises that strengthen muscles and improve stamina may be most effective.7 You should avoid activities that cause excess pain in your joints.2
Another option to relieve your knee pain is drug therapy such as non-prescription pain relievers (like acetaminophen) or drugs that reduce inflammation, including ibuprofen, aspirin, or naproxen, or prescription medication such as narcotics. If these options do not work well enough, other treatments that may be considered include knee injections with a corticosteroid (cortisone) or a hyaluronate (like TRILURON®) or surgery.2
TRILURON® is used to relieve knee pain due to osteoarthritis for people who do not get enough relief from simple pain medications (e.g., acetaminophen), exercise, and physical therapy. A clinical study has shown that TRILURON® is an effective treatment option for patients with knee OA pain.1
You should not take this product if you have had any previous allergic reaction to TRILURON® or similar material, e.g., hyaluronate products. You should not have an injection into the knee if you have infections or skin diseases around the injection site.2
1. TRILURON® [package insert]. Abano Terme, Italy: Fidia Farmaceutici; July 2019. 2. TRILURON® [patient information]. Fidia Farmaceutici, July 2019. 3. Deshpande BR, Katz JN, Solomon DH, et al. Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity. Arthritis Care Res. 2016;68(12):1743-1750. 4. American Academy of Orthopaedic Surgeons. About Your Knee. https://orthoinfo.aaos.org/globalassets/pdfs/about-your-knee.pdf. Accessed January 24, 2020. 5. American Academy of Orthopaedic Surgeons. Arthritis of the Knee. https://orthoinfo.aaos.org/en/diseases--conditions/arthritis-of-the-knee. Accessed January 24, 2020. 6. Parmet S, Lynm C, Glass RM. JAMA patient page. Osteoarthritis of the knee. JAMA. 2003;289(8):1068. 7. Arthritis Foundation. Osteoarthritis. https://www.arthritis.org/diseases/osteoarthritis. Accessed January 24, 2020. 8. Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115-26.