TRILURON^® improves lubrication and reduces friction compared with several other commercially available hyaluronic acid (HA) products^1,a

Study design: Bovine articular cartilage was pressed against polished glass while bathed in commercially available HA products. While pressed, the cartilage was slid at predetermined speeds (0.1 mm/sec to 10 mm/sec) to represent the sliding speeds of a possible range of daily activities. During sliding, both compression and friction forces were measured to calculate the friction coefficient.

Friction reduction was seen across a wide range of sliding speeds that may represent a possible range of daily activities¹

^aPreclinical test data may not be indicative of human clinical outcomes.
^bThe HA in TRILURON^® is the same chemical formulation as the HA in HYALGAN^®.
Third-party trademarks used herein are trademarks of their respective owners.

Indication

TRILURON^® is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy, and to simple analgesics, e.g., acetaminophen.

Important Safety Information

TRILURON^® is contraindicated in patients with known hypersensitivity to hyaluronate preparations or patients with infections/skin diseases in the area of the injection site/joint. The safety and effectiveness of TRILURON^® have not been established in pregnant women, nursing mothers, children, use in other joints, or concomitantly with other intra-articular (IA) injections. The effectiveness of a single treatment cycle of less than 3 injections has not been established.

Anaphylactoid and allergic reactions have been reported with this product. Transient increases in inflammation in the injected knee following TRILURON^® injection have been reported in some patients with inflammatory arthritis. Common adverse events include joint effusion/swelling/pain, injection site pain/hematoma, local skin reactions (rash, ecchymosis) and injection site warmth. Usually, local adverse events are transient and disappear spontaneously within a few days of resting the affected joint and/or applying ice locally. See package insert for full warnings, precautions and adverse events for more detail.

Rx Only.

Please see Full Prescribing Information.

TRILURON® improves lubrication and reduces friction compared with several other commercially available hyaluronic acid (HA) products1,a

Friction reduction was seen across a wide range of sliding speeds that may represent a possible range of daily activities1

References

TRILURON^® improves lubrication and reduces friction compared with several other commercially available hyaluronic acid (HA) products^1,a

Friction reduction was seen across a wide range of sliding speeds that may represent a possible range of daily activities¹