TRILURON^® delivers effective and sustained pain relief with just 3 injections²

reduction in
mean WOMAC pain
subscale scores from
baseline at 6 months
‒18.4 ± 1.5 mm
(mean ± SE)

reduction in mean
global VAS knee pain
from baseline
‒ 26.7 mm
(range ‒30.0 to ‒23.4)

met the minimum OARSI/OMERACT responder rate for improvement in pain and function

met the MCII Pain responder rate, with 56% meeting the MCII Function responder rate

MCII, minimum clinically important improvement; OARSI, Osteoarthritis Research Society International; OMERACT, outcome measures in rheumatology; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index

Indication

TRILURON^® is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy, and to simple analgesics, e.g., acetaminophen.

Important Safety Information

TRILURON^® is contraindicated in patients with known hypersensitivity to hyaluronate preparations or patients with infections/skin diseases in the area of the injection site/joint. The safety and effectiveness of TRILURON^® have not been established in pregnant women, nursing mothers, children, use in other joints, or concomitantly with other intra-articular (IA) injections. The effectiveness of a single treatment cycle of less than 3 injections has not been established.

Anaphylactoid and allergic reactions have been reported with this product. Transient increases in inflammation in the injected knee following TRILURON^® injection have been reported in some patients with inflammatory arthritis. Common adverse events include joint effusion/swelling/pain, injection site pain/hematoma, local skin reactions (rash, ecchymosis) and injection site warmth. Usually, local adverse events are transient and disappear spontaneously within a few days of resting the affected joint and/or applying ice locally. See package insert for full warnings, precautions and adverse events for more detail.

Rx Only.

Please see Full Prescribing Information.

TRILURON® delivers effective and sustained pain relief with just 3 injections2

References

TRILURON^® delivers effective and sustained pain relief with just 3 injections²